KMID : 0356720060220060387
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Journal of the Korean Society of Coloproctology 2006 Volume.22 No. 6 p.387 ~ p.395
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Trend of Clinicopathologic Characteristics of Colorectal Cancer in Asan Medical Center: a 15-Year Experience
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Choi Pyong-Wha
Jung Sang-Hun Kim Jung-Rang Yu Chang-Sik Kim Hee-Cheol Kim Jin-Cheon
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Abstract
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Purpose: A retrospective study was performed to provide an overview of changes over time by age, stage, tumor location, and surgical therapy of colorectal cancer over the past 15 years.
Methods: We analyzed the cases 6,314 colorectal cancer patients who underwent surgery at Asan Medical Center between January 1990 and December 2004. The period was divided into three periods: 1990 to 1994, 1995 to 1999, and 2000 to 2004. We analyzed trends over time for stage, resectability, and demographic factors of colorectal cancer over the past 15 years.
Results: The mean age of the patients in the periods from 1990 to 1994, from 1995 to 1999, and from 2000 to 2004 were 57.1 (21~89), 57.4 (14~91), and 58.9 (15~91) years, respectively, showing an increasing tendency over time (P£¼0.001). The male-to-female ratios were 1.2£º1, 1.3£º1, and 1.6£º1, repectively, and this male preponderance has been more marked in recent years (P=0.003). There was no change in tumor location over time. The ratios of early cancer to advanced cancer were 0.06£º1, 0.09£º1, and 0.11£º1, respecfively, showing an increasing tendency over time (P=0.002). The curative resection rate increased over time (P£¼0.001). The non-curative resection rate was higher and the non-resected rate was lower in the period 2000 to 2004 than in the period 1990 to 1999 (P£¼0.001). The ratios of the lowest anterior resection to the abdominoperineal resection were 0.06£º1, 0.49£º1, and 1.02£º1, respectively. With decreasing tendency of abdominoperineal resection, the lowest anterior resection rate has increased gradually over time (P£¼0.001).
Conclusion: Etiologic studies are necessary to understand the male preponderance in colorectal cancer, and multi-center studies should be conducted to understand the changing trend of colorectal cancer in Korea. J Korean Soc Coloproctol 2006;22:387-395
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KEYWORD
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Colorectal cancer, Trend, Stage
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